Is the end of men nigh? As Hannah Rosin reports, women have come to dominate the post-industrial market, taking more degrees, more jobs, and more managerial roles than men in 2010 — for the first time in American history. And if anyone is in a position to permanently ice all bros forever, it’s the women whom Fast Company named the most influential women tech players of 2010.

Not only have these women overcome the long odds associated with the boys’ clubs of engineering and entrepreneurship, they’re making the blueprint for the next generation of women to follow. If they can keep a lid on the Caitlin Flanagans, the next generation of women is going to enjoy awesome, unprecedented freedom. The hope is that by then men will have stopped pouring vodka into one another’s eyeballs or whatever.