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Officials encourage event-goers to use public transit and others to avoid the area.
The event is slated for November 28.
Beginning at 10 a.m., folks can enter the lottery online or by calling 877-444-6777.
“Before we leave tonight, I just want to express what an incredible honor it has been to serve this country, and feel its warmth, and to feel its generosity,” Obama said.
The lottery will be open from October 7 until October 10.