After a mainly virtual event in 2021, the annual March for Life, the nation’s largest anti-abortion protest, is coming back to D.C. on Friday.

The day will begin with a concert at 11 a.m., followed by a rally on the National Mall at noon/ The march will start around 1 p.m. between 12th and 14th Streets, and end on the steps of the Supreme Court.

The following streets will be closed to parking from 6 a.m.-4 p.m., and closed to vehicular traffic from around 10 a.m.-4 p.m., according to the Metropolitan Police Department. Exact times are subject to change, so residents should follow D.C. Police Traffic for updates on Friday.

• Constitution Avenue from 14^th Street, NW to 2^nd Street NE
• Pennsylvania Avenue from 7^th Street, NW to 3^rd Street NW
• 12^th Street from Pennsylvania Avenue, NW to Madison Drive NW
• 12^th Street Tunnel
• 10^th Street from Pennsylvania Avenue, NW to Constitution Avenue NW
• 9^th Street from Pennsylvania Avenue, NW to Constitution Avenue NW
• 9^th Street Tunnel
• 7^th Street from Pennsylvania Avenue, NW to Independence Avenue SW
• 6^th Street from Pennsylvania Avenue, NW to Constitution Avenue NW
• 4^th Street from Pennsylvania Avenue, NW to Independence Avenue SW
• 3^rd Street from C Street, NW to Independence Avenue SW

A National Park Service permit for the march estimates around 50,000 people will attend — a smaller crowd than in years past, in part due to the pandemic. A scan of discussion posts on the March for Life website and comments on the march’s Facebook page show that D.C.’s vaccine mandate for businesses — decried repeatedly by conservative pundits and members of Congress — might also drive down attendance. The march’s website contains a lengthy question-and-answer post entitled, “WHAT IMPACT DOES WASHINGTON DC’S RECENT VACCINE MANDATE HAVE ON THE 2022 MARCH FOR LIFE?” A dinner gala after the march will be taking place at the Renaissance Hotel downtown, where guests will be required to show proof of vaccination to attend (but not to book a room). Organizers are also requiring masks when not eating or drinking.

It’ll be a busy weekend downtown, with another rally — a national protest against vaccine mandates on the National Mall — set for Sunday. Organizers of the “Defeat the Mandates: An American Homecoming” march and rally submitted a permit to the National Park Service for 20,000 attendees. Although organizers told DCist/WAMU that protesters should not disrupt local businesses, some locals are worried about D.C.’s food and hospitality workers and possible confrontations with anti-vaccine protesters. So far, MPD has not issued any road closures for Sunday’s event.